Perricone MD Neuropeptide Deep Crease Serum is formulated with a neuropeptide complex designed to target the appearance of deep facial wrinkles and expression lines. Neuropeptides are signaling molecules that support the skin’s natural repair processes, helping to smooth and refine the look of pronounced creases over time. The serum also includes a blend of hydrating and conditioning ingredients that work to improve surface texture and maintain moisture balance.

This lightweight, fast-absorbing formula is intended for daily use on cleansed skin, applied gently to areas where deeper lines are most noticeable, such as the forehead, around the eyes, and along the nasolabial folds. Its non-greasy texture allows for easy layering under moisturizers or makeup without pilling. The product is suitable for a variety of skin types, including mature or sun-damaged skin that may benefit from additional support for visible creases.

The 1 fl oz bottle provides a reasonable supply for regular application over several weeks. Perricone MD emphasizes a science-backed approach to skincare, and this serum fits within a broader regimen aimed at addressing signs of aging through targeted peptides and antioxidant support. As with any concentrated treatment, patch testing is recommended for those with sensitive skin. The formulation avoids common irritants and is free from parabens and sulfates, contributing to a gentler user experience. Consistent use as directed may help diminish the look of deep-set wrinkles, though individual results depend on factors such as skin condition, age, and lifestyle habits. This product is intended for external use only and should be stored away from direct sunlight.